Bone Morphogenic Proteins

By | April 20, 2015

BMP2 is the protein most commonly used to promote fusion in spinal surgery.

BMP2 is the protein most commonly used to promote fusion in spinal surgery.

Bone morphogenic proteins (BMP) are a group of 20 proteins originally isolated and studied in bone, which control the synthesis, remodeling and absorption of bone. In addition to their actions on bone, some of these proteins have been shown to control homeostasis and repair in the kidney as well as promoting some types of cancers and inhibiting others. The synthesis of these proteins using recombinant DNA techniques was critical in issuing in the modern era of spine surgery. Before their routine use, one of the most feared complications of spinal surgery was failure to fuse. This usually left the patient with an unstable spine and increased pain. Operations were designed firstly to promote fusion usually at the cost of larger dissections and often autologous bone harvest, a very painful procedure. With the routine use of BMP and the near 100% fusion rates that it produces, attention could be directed toward minimally invasive techniques with decreased pain and more rapid convalescence.  Virtually all fusions performed on our patients here at Schlesinger Pain Centers a done using BMP.


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